Journal: International journal of antimicrobial agents

Article Title: Antibacterial and antivirulence activities of auranofin against Clostridium difficile

doi: 10.1016/j.ijantimicag.2018.09.018

Figure Lengend Snippet: The minimum inhibitory concentration (MIC, µg/mL) of auranofin and control drugs against vancomycin-resistant Enterococcus faecium isolates.

Article Snippet: Auranofin, linezolid (Chem-Impex International, Wood Dale, IL), vancomycin hydrochloride (Gold Biotechnology, St. Louis, MO) metronidazole (Beantown Chemical Corporation, Hudson, NH), sodium selenite (MP Biomedicals, Santa Ana, CA), and fidaxomicin (Apexbio, Houston, TX) were procured from commercial vendors.

Techniques: Concentration Assay

Journal: Journal of medicinal chemistry

Article Title: Discovery of Aromatic Carbamates that Confer Neuroprotective Activity by Enhancing Autophagy and Inducing the Anti-Apoptotic Protein B-Cell Lymphoma 2 (Bcl-2)

doi: 10.1021/acs.jmedchem.7b01199

Figure Lengend Snippet: Protective Effect of Benzylamine Analogues of 1 to Ameliorate Etoposide-Induced Apoptosis in PC12 Cells (n = 3, Percentage Cell Viability Represented As Mean ± SEM)

Article Snippet: The cells were pretreated (4 h) with the test compound and incubated with 15 μ g/mL etoposide (Chem-Impex International, 28435).

Techniques: Analogues

Journal: Journal of medicinal chemistry

Article Title: Discovery of Aromatic Carbamates that Confer Neuroprotective Activity by Enhancing Autophagy and Inducing the Anti-Apoptotic Protein B-Cell Lymphoma 2 (Bcl-2)

doi: 10.1021/acs.jmedchem.7b01199

Figure Lengend Snippet: Protective Effect of Carbamate Analogues of 1 to Ameliorate Etoposide-Induced Apoptosis in PC12 Cells (n = 3, Percentage Cell Viability Represented As Mean ± SEM)

Article Snippet: The cells were pretreated (4 h) with the test compound and incubated with 15 μ g/mL etoposide (Chem-Impex International, 28435).

Techniques: Analogues

Journal: Journal of medicinal chemistry

Article Title: Discovery of Aromatic Carbamates that Confer Neuroprotective Activity by Enhancing Autophagy and Inducing the Anti-Apoptotic Protein B-Cell Lymphoma 2 (Bcl-2)

doi: 10.1021/acs.jmedchem.7b01199

Figure Lengend Snippet: Protective Effect of Ring Analogues of 1 to Ameliorate Etoposide-Induced Apoptosis in PC12 Cells (n = 3, Percentage Cell Viability Represented As Mean ± SEM

Article Snippet: The cells were pretreated (4 h) with the test compound and incubated with 15 μ g/mL etoposide (Chem-Impex International, 28435).

Techniques: Analogues

Journal: Journal of medicinal chemistry

Article Title: Discovery of Aromatic Carbamates that Confer Neuroprotective Activity by Enhancing Autophagy and Inducing the Anti-Apoptotic Protein B-Cell Lymphoma 2 (Bcl-2)

doi: 10.1021/acs.jmedchem.7b01199

Figure Lengend Snippet: Protective Effect of Hybrid Analogues of 1 to Ameliorate Etoposide-Induced Apoptosis in PC12 Cells (n = 3, Percentage Cell Viability Represented As Mean ± SEM)

Article Snippet: The cells were pretreated (4 h) with the test compound and incubated with 15 μ g/mL etoposide (Chem-Impex International, 28435).

Techniques: Analogues

Journal: Journal of medicinal chemistry

Article Title: Discovery of Aromatic Carbamates that Confer Neuroprotective Activity by Enhancing Autophagy and Inducing the Anti-Apoptotic Protein B-Cell Lymphoma 2 (Bcl-2)

doi: 10.1021/acs.jmedchem.7b01199

Figure Lengend Snippet: Summary of protective activity of selected aromatic carbamates to ameliorate etoposide-induced apoptosis in PC12 cells at low concentrations. Two-Way ANOVA, Tukey test, 95% confidence interval. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001. n = 3, % viability represented as mean ± SEM.

Article Snippet: The cells were pretreated (4 h) with the test compound and incubated with 15 μ g/mL etoposide (Chem-Impex International, 28435).

Techniques: Activity Assay

Journal: Journal of medicinal chemistry

Article Title: Discovery of Aromatic Carbamates that Confer Neuroprotective Activity by Enhancing Autophagy and Inducing the Anti-Apoptotic Protein B-Cell Lymphoma 2 (Bcl-2)

doi: 10.1021/acs.jmedchem.7b01199

Figure Lengend Snippet: Selected aromatic carbamates are protective to ameliorate etoposide-induced apoptosis in human SH-SY5Y cells. Cell viability measured using PrestoBlue dye after treatment with 5 μM etoposide for 12 h. Two-Way ANOVA, Tukey test, 95% confidence interval. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001. n = 3, % viability represented as mean ± SEM.

Article Snippet: The cells were pretreated (4 h) with the test compound and incubated with 15 μ g/mL etoposide (Chem-Impex International, 28435).

Techniques:

Journal: Journal of medicinal chemistry

Article Title: Discovery of Aromatic Carbamates that Confer Neuroprotective Activity by Enhancing Autophagy and Inducing the Anti-Apoptotic Protein B-Cell Lymphoma 2 (Bcl-2)

doi: 10.1021/acs.jmedchem.7b01199

Figure Lengend Snippet: Selected aromatic carbamates ameliorate etoposide-induced apoptosis in human IMR90-c4 iPSC-derived neurons. Cell viability measured using PrestoBlue dye after treatment with 15 μg/mL etoposide for 36 h. Two-Way ANOVA, Tukey test, 95% confidence interval. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001. n = 3, % viability represented as mean ± SEM.

Article Snippet: The cells were pretreated (4 h) with the test compound and incubated with 15 μ g/mL etoposide (Chem-Impex International, 28435).

Techniques: Derivative Assay